Snowball project Overview

Joint Programme - Neurodegenerative Disease Research

Interplay of amyloid and ischemia and their influence on blood-brain barrier, amyloid transportation systems and neurodegeneration in cerebral amyloid angiopathy (CAA)


Due to the increasing number of older people Alzheimer dementia (AD) and stroke are both diseases with high socioeconomic impact. Recent results document that patients with AD have more microinfarcts than do control subjects, and that the number of microinfarcts correlates with global cognitive performance. In the case of cerebral amyloid angiopathy (CAA) patients do not only establish dementia but also microbleeds, lobar hermorrhages and ischemic stroke. Further studies support the notion that cerebrovascular injuries and AD not only occur together but also interact, leading to a snowball effect in disease manifestation.  Overall the SNOWBALL joint project focusses the combination of the deteriorating effects of ischemic insults on the outcome of dementia with regard to cerebrovascular dysfunction and Aß disposition in comparison to the chain of toxic events occurring either after stroke or beginning amyloid angiopathy.



Project Coordinator


Prof. Dr. Marc Fatar

Department of Neurology
Universitätsmedizin Mannheim

Phone: +49 621 383-3953

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